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Center for Critical Assessment of Genome Interpretation (CAGI) – Evaluation of Computational Methods for Prediction of Genome Variation

In his presentation, Dr. Brenner will introduce the CAGI (\'kâ-jê\), acommunity experiment to objectively assess computational methods for predictingthe phenotypic impacts of genomic variation. In the experiment, participantsare provided genetic variants and make predictions of resulting phenotype forten challenges. These predictions are evaluated against experimentalcharacterizations by independent assessors. He will describe findings fromprevious CAGI challenges. In brief, CAGI revealed that despite statisticallysignificant predictions, accuracy on the phenotypic impact of any specificvariant was of questionable clinical utility. The most effective predictionscame for methods honed to the precise challenge. Opportunities for furtherprogress remain. The talk will provide updates on the current CAGI4 challengeseason and discuss opportunities for genetic researchers to participate. TheCAGI4 meeting will be held March 24-27, 2016.

Thursday, February 18, 2016

Steven E. Brenner, PhD

Monday, February 29, 2016

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